BAP1 as Independent Cause
Recent reviews of genetic research continue to challenge long-held assumptions about the causes of malignant mesothelioma. While plaintiffs’ attorneys often cite to asbestos exposure as the only cause of mesothelioma, a January 2025 publication in Scientific Reports led by Dahlia Nielsen includes a novel approach to the subject and provides further evidence that certain inherited genetic mutations—most notably in the BAP1 gene—can independently cause mesothelioma, even in the absence of asbestos exposure.1 The results of Nielsen’s Bayesian analysis and findings, together with a brand new paper2 by Dr. Michele Carbone’s group (which may find its way into a future blog), may alter the landscape of asbestos litigation and influence the strategies used by both plaintiffs and defendants.
